Toxicity of fenpropathrin, phoxim and its mixture to silkworm were tested by food intake method and contact method. The LD50 and its 95% confidence limits of pesticides by food intake method were fenpropathrin 0.043 73 (0.042 8~0.044 7) μg/mL; phoxim 0.703 7 (0.695~0.712) μg/mL; the mixture 0.112 3 (0.107~0.118) μg/mL. The LD50 and its 95% confidence limits of pesticides by contact method were: fenpropathrin 0.717 (0.664~0.770) μg/mL; phoxim 27.15 (24.74~29.56) μg/mL; the mixture 4.384 (3.943~4.826) μg/mL. The toxicity of fenpropathrin and phoxim was evaluated by Finney method and result showed that it was combined action.