硒
螺旋藻(膳食补充剂)
化学
抗氧化剂
细胞凋亡
药理学
上睑下垂
肝损伤
体内
生物化学
程序性细胞死亡
生物
生物技术
有机化学
原材料
作者
Xiang Fu,Zhiwen Zhong,Feng Hu,Yi Zhang,Chunxia Li,Peng Yan,Lixue Feng,Jinglian Shen,Bei Huang
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2018-01-01
卷期号:9 (6): 3155-3165
被引量:25
摘要
The aim of this study was to investigate the protective effect and mechanism of selenium-enriched Spirulina platensis (S. platensis) on chronic alcohol-induced liver injury. Selenium incubation raises the nutrition quality of S. platensis by absorption enhancement of functional elements. Our results demonstrated that the effective dose of selenium-enriched S. platensis on HL7702 cells treated with alcohol was 200 μg ml-1, containing 20% selenium. Selenium-enriched S. platensis could raise the cell survival rate by decreasing the expression of p53, Caspase3, LC3, and Caspase1 and by increasing the expression of p70s6k. In vivo experiments, where mice were pretreated with selenium-enriched S. platensis, exhibited obvious inhibition of the liver function index and this pretreatment enhanced the activity of GSH-Px and SOD in alcohol induced mice. In summary, our results indicate that the protective mechanism of selenium-enriched S. platensis on chronic alcoholic liver injury is associated with the activity enhancement of antioxidant enzymes and immunity, the inhibition of DNA damage and apoptosis, accompanied with autophagy and pyroptosis.
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