化学
脱羧
芳基
催化作用
组合化学
溶剂
非甾体
级联
铜
配体(生物化学)
有机化学
乌尔曼反应
联轴节(管道)
受体
生物化学
医学
工程类
烷基
药理学
色谱法
机械工程
作者
Fei Cheng,Tao Chen,Yin-Qiu Huang,Jiawei Li,Chen Zhou,Xiao Xiao,Fen‐Er Chen
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-12-21
卷期号:24 (1): 115-120
被引量:16
标识
DOI:10.1021/acs.orglett.1c03688
摘要
We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.
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