光热治疗
光动力疗法
光敏剂
卟啉
抗菌剂
细菌
阳离子聚合
光热效应
化学
需氧菌
光化学
微生物学
纳米技术
材料科学
生物
有机化学
遗传学
作者
Hao Hu,Hua Wang,Yuchong Yang,Jiang‐Fei Xu,Xi Zhang
标识
DOI:10.1002/anie.202200799
摘要
We report a cationic porphyrin 5,10,15,20-tetrakis-(4-N-methylpyridyl)-porphyrin (TMPyP) that can respond to specific bacteria, followed by adaptable photodynamic/photothermal therapy processes. TMPyP could be reduced to phlorin by facultative anaerobes with a strong reducing ability such as E. coli and S. typhimurium in hypoxic environments, possessing strong NIR absorption and remarkable photothermal conversion capacity, thus demonstrating excellent antimicrobial activity (>99 %) by photothermal therapy. While in an aerobic environment with aerobic bacteria, TMPyP functioned as a typical photosensitizer that killed bacteria effectively (>99.9 %) by photodynamic therapy. By forming a host-guest complex with cucurbit[7]uril, the biocompatibility of TMPyP significantly improved. This kind of bacteria-responsive porphyrin shows specificity and adaptivity in antimicrobial treatment and holds potential in non-invasive treatments of bacterial infections.
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