嘧啶
尿嘧啶
生物活性
化学
胸腺嘧啶
胞嘧啶
嘧啶代谢
生物化学
药理学
DNA
生物
体外
嘌呤
酶
作者
Ramalakshmi Natarajan,N. Helina,S. Amuthalakshmi,S. Arunkumar
出处
期刊:Medicinal Chemistry
日期:2023-01-01
卷期号:19 (1): 10-30
被引量:7
标识
DOI:10.2174/1573406418666220509100356
摘要
Heterocycles play a major role in many fields of biochemical and physiological such as amino acids, DNA bases, vitamins, endogenous neurotransmitters, etc. Nitrogencontaining heterocyclic compounds play a vital role in medicinal chemistry and exhibit notable biological and pharmacological activities. In the past two decades, scientists focused more on the diverse biological activities of pyrimidine derivatives. Pyrimidine is a six-membered heterocyclic compound, and it is present naturally in nucleic acid components (uracil, thymine, and cytosine) and vitamin B1; it is a promising lead molecule for synthesising compounds with various substitutions to treat various diseases.We focused on the structure-activity relationship of pyrimidine derivatives and its various biological activities reported from 2010 to date.From this review, we concluded that the position of substituents in the pyrimidine nucleus greatly influences biological activities. Thus, the pyrimidine nucleus showed anti-microbial, anticancer, anti-inflammatory, anti-tubercular, anti-convulsant, antihypertensive, anthelmintic, antidepressant, analgesic, anti-hyperglycemic activities, etc. Conclusion: This study provides an overview of the pyrimidine nucleus and its derivatives from 2010 to date. There is a future scope for identifying a lead molecule for the target biological activity.
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