内脏利什曼病
杜氏利什曼原虫
婴儿利什曼原虫
生物
利什曼病
病毒学
沙蝇
利什曼原虫
寄生虫寄主
载体(分子生物学)
免疫学
遗传学
基因
重组DNA
计算机科学
万维网
作者
Mohammad Ali Oshaghi,Naseh Maleki‐Ravasan,Mallorie Hide,E Javadian,Yavar Rassi,Javid Sadraei,Mehdi Mohebali,Mohammad Mehdi Sedaghat,Homa Hajjaran,Zabihollah Zarei,Fatemeh Mohtarami
标识
DOI:10.1016/j.exppara.2009.07.004
摘要
Leishmania infantum is the causative agent of infantile visceral leishmaniasis (IVL) in the Mediterranean Basin and, based on isoenzyme typing of the parasite isolated from dogs; this parasite was considered to predominate in the all foci of IVL in Iran. However, based on PCR detection and sequencing of parasite Cysteine Protease B (CPB), only one out of seven sandfly infections in Phlebotomus perfiliewi transcaucasicus was found to be L. infantum in the current investigation. The six other infections were haplotypes of Leishmania donovani, the causative agent of anthroponotic visceral leishmaniasis (AVL) in West Africa and India. The deduced amino acid of the L. donovani haplotype was found to be novel and the shortest CPB protein reported within the Leishmania spp. Circulation of both L. donovani and L. infantum by P. perfiliewi transcaucasicus, in addition to previous data indicating its ability to circulate L. tropica, suggests that this species, like other vectors of VL, is a permissive vector. Finding L. donovani infecting P. perfiliewi transcaucasicus in the area demands extensive and intensive typing of natural Leishmania infections in epidemiological investigations in Iran and the Mediterranean Basin in general.
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