Multimode optical imaging for translational chemotherapy: in vivo tumor detection and delineation by targeted gallium corroles

荧光寿命成像显微镜 荧光 体内 临床前影像学 材料科学 多模光纤 光学 医学影像学 分子成像 光动力疗法 离体 核磁共振 光纤 物理 化学 医学 放射科 生物 生物技术 有机化学
作者
Jae Youn Hwang,Zeev Gross,Harry B. Gray,Lali K. Medina‐Kauwe,Daniel L. Farkas
出处
期刊:Proceedings of SPIE 卷期号:7902: 79020F-79020F 被引量:4
标识
DOI:10.1117/12.877780
摘要

We report the feasibility of tumor detection and delineation in vivo using multimode optical imaging of targeted gallium corrole (HerGa). HerGa is highly effective for targeted HER2+ tumor elimination in vivo, and it emits intense fluorescence. These unique characteristics of HerGa prompted us to investigate the potential of HerGa for tumor detection and delineation, by performing multimode optical imaging ex vivo and in vivo; the imaging modes included fluorescence intensity, spectral (including ratiometric), lifetime, and two-photon excited fluorescence, using our custom-built imaging system. While fluorescence intensity imaging provided information about tumor targeting capacity and tumor retention of HerGa, ratiometric spectral imaging offered more quantitative and specific information about HerGa location and accumulation. Most importantly, the fluorescence lifetime imaging of HerGa allowed us to discriminate between tumor and non-tumor regions by fluorescence lifetime differences. Finally, two-photon excited fluorescence images provided highly resolved and thus topologically detailed information around the tumor regions where HerGa accumulates. Taken together, the results shown in this report suggest the feasibility of tumor detection and delineation by multimode optical imaging of HerGa, and fluorescent chemotherapy agents in general. Specifically, the multimode optical imaging can offer complementary and even synergetic information simultaneously in the tumor detection and delineation by HerGa, thus enhancing contrast.

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