The problems related to the physical processes which occurred during tissues irradiation by laser radiation, from the range of 2 ÷ 3 μm, generated by holmium laser (λ= 2.1 μm) and erbium laser (λ = 2.9 μm), are considered in the article. The interaction of radiation of lasers generating radiation within the above mentioned range is very important problem because in case of high values of the absorption coefficient of radiation in the tissues, the additional interaction mechanisms influencing energy transfer occurs. The radiation energy distribution and temperatures of the irradiated tissue are compared for the chosen types of lasers.