Discovering Drugs through Biological Transformation: Role of Pharmacologically Active Metabolites in Drug Discovery

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTDiscovering Drugs through Biological Transformation: Role of Pharmacologically Active Metabolites in Drug DiscoveryAberra Fura, Yue-Zhong Shu, Mingshe Zhu, Ronald L. Hanson, Vikram Roongta, and W. Griffith HumphreysView Author Information Bristol Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08534, Bristol-Myers Squibb, Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, Bristol Myers Squibb, Pharmaceutical Research Institute, P.O. Box 4000, Princeton, New Jersey 08543, and Bristol-Myers Squibb, Pharmaceutical Research Institute, One Squibb Drive, New Brunswick, New Jersey 08903 Cite this: J. Med. Chem. 2004, 47, 18, 4339–4351Publication Date (Web):July 29, 2004Publication History Received18 March 2004Published online29 July 2004Published inissue 1 August 2004https://doi.org/10.1021/jm040066vCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views2661Altmetric-Citations120LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (168 KB) Get e-AlertscloseSUBJECTS:Anatomy,Drug discovery,Metabolism,Peptides and proteins,Pharmaceuticals Get e-Alerts