Enantioselective Synthesis of Heterocycles

Significance Building upon previous work the authors report a cooperative catalyst system ­consisting of a cinchona alkaloid and Ti(O i -Pr) 4 for the enantioselective synthesis of heterocycles (N. Shibata, T. Toru and co-workers Synlett 2006 , 3484). The heterocycles formed in this manner possess a quaternary center bearing a trifluoro­methyl group. These novel heterocycles could be potentially interesting from a medicinal chemistry perspective.