神经酰胺
脂肪组织
胰岛素
内分泌学
内科学
胰岛素抵抗
鞘脂
脂滴
脂肪酸
白色脂肪组织
生物化学
化学
医学
细胞凋亡
作者
Rima Hage Hassan,Olivier Bourron,Eric Hajduch
出处
期刊:World Journal of Diabetes
[Baishideng Publishing Group Co (World Journal of Diabetes)]
日期:2014-06-15
卷期号:5 (3): 244-244
被引量:57
标识
DOI:10.4239/wjd.v5.i3.244
摘要
In healthy people, balance between glucose production and its utilization is precisely controlled. When circulating glucose reaches a critical threshold level, pancreatic β cells secrete insulin that has two major actions: to lower circulating glucose levels by facilitating its uptake mainly into skeletal muscle while inhibiting its production by the liver. Interestingly, dietary triglycerides are the main source of fatty acids to fulfill energy needs of oxidative tissues. Normally, the unconsumed fraction of excess of fatty acids is stored in lipid droplets that are localized in adipocytes to provide energy during fasting periods. Thus, adipose tissue acts as a trap for fatty acid excess liberated from plasma triglycerides. When the buffering action of adipose tissue to store fatty acids is impaired, fatty acids that build up in other tissues are metabolized as sphingolipid derivatives such as ceramides. Several studies suggest that ceramides are among the most active lipid second messengers to inhibit the insulin signaling pathway and this review describes the major role played by ceramide accumulation in the development of insulin resistance of peripherals tissues through the targeting of specific proteins of the insulin signaling pathway.
科研通智能强力驱动
Strongly Powered by AbleSci AI