Causal impact of obesity class stratification and endometrial cancer subtypes: an integrated Mendelian randomization and Global Burden of Disease Study 2021 analysis

An elevated body mass index (BMI) is a modifiable causal factor for uterine cancer, especially endometrial cancer. This type of cancer disproportionately affects older populations and regions with high socio-demographic indices (SDI). Findings from Mendelian randomization (MR) and the Global Burden of Disease (GBD) highlight the urgent need for targeted obesity interventions to reduce disease burden in vulnerable populations.