Effect of Oral Tranexamic Acid on Hair Melanin in Asian Women

Introduction: Tranexamic acid (TXA) is widely used to treat melasma, but its potential effects on hair pigmentation remain unexplored. Concerns about hair whitening during TXA treatment have been raised, as it is often perceived as a sign of aging and may elicit negative emotional responses. This study aimed to evaluate the effects of oral TXA on hair melanin content and color. Methods and Results: Seven middle‐aged East Asian women completed a 3‐month prospective observational study, taking 500‐mg oral TXA daily, excluding menstruation periods. Hair samples were collected from 10 scalp regions before and after treatment. Melanin content was measured using liquid chromatography–tandem mass spectrometry, and hair color changes were assessed with a colorimeter. One participant was excluded due to hair dyeing during the study. After 3 months of TXA treatment, no statistically significant changes in hair melanin content or hair color were observed, even after accounting for individual differences. Discussion: Oral TXA administered at 500 mg daily for 3 months did not significantly affect hair melanin content or color in middle‐aged East Asian women. These findings provide reassurance for patients and clinicians regarding hair pigmentation during TXA treatment. Further research with diverse populations is recommended. Trial Registration: Chinese Registry of Clinical Trials: ChiCTR2400092219