医学
球蛋白
丙种球蛋白
抗体
血清蛋白电泳
内科学
白蛋白
胃肠病学
免疫学
单克隆
单克隆抗体
作者
Osman Ozan Yeğit,Pelin Karadağ,Deniz Eyice,Nida Oztop,Sengul Beyaz,Özdemir Can Tüzer,Ali Can,Semra Demir,Derya Erdoğdu,Halim Issever,Sema Genç,Beyhan Ömer,Stephen Jolles,Aslı Gelincik
出处
期刊:International Archives of Allergy and Immunology
[S. Karger AG]
日期:2023-04-25
卷期号:: 1-10
摘要
<b><i>Introduction:</i></b> Heterogeneous clinical features of antibody deficiency (AD) may cause diagnostic delays. Calculated globulin (CG) (total protein minus albumin) has been proposed as a screening test to prevent morbidity due to diagnostic delays in AD. Our aim was to validate CG as a screening test for AD in Turkish adult patients by comparing its role with gamma globulin analysis in protein electrophoresis. <b><i>Methods:</i></b> Fifty serum samples were randomly collected for each level of CG from 15 to 25 g/L and tested for serum IgG, IgA, IgM levels and protein electrophoresis. Cut-off values predicting low IgG levels were calculated for electrophoretically determined gamma globulin and CG. Additionally, the data of 47 patients followed up in our clinic with a diagnosis of primary antibody deficiency (PAD) were retrospectively analyzed. <b><i>Results:</i></b> A total of 550 adult patients were included in the study. The CG value predicting patients with IgG <6 g/L as a screening test was determined as <20 g/L with 83.8% sensitivity and 74.9% specificity. The gamma globulin value which predicted patients with the same IgG value of 89.0% sensitivity and 89.4% specificity was determined as <7 g/L. In the retrospective analysis, 37 of 47 patients (78.7%) with PAD had a CG value of <20 g/L at the time of the diagnosis and all 13 patients (100%) whose gamma globulin values were measured at the time of the diagnosis had a gamma globulin value of <7 g/L. <b><i>Conclusion:</i></b> The determined CG cut-off value of <20 g/L can be used as a screening test in Turkish adult patients.
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