Focused ultrasound treatment of cervical human papillomavirus infection and squamous intraepithelial lesions: A narrative review

Focused ultrasound (FUS) appears to be a promising form of thermal ablation for treatment of cervical lesions, but evidence supporting its use is limited. This review evaluated the efficacy and safety of FUS treatment of cervical human papillomavirus (HPV) infection and squamous intraepithelial lesions (SIL). The overall efficacy of FUS on HPV clearance was 75.0-85.7 % at 3 months, 35.5-77.1 % at 6 months and 64.7-94.1 % at 12 months. Its efficacy on low grade SIL and high grade SIL regression were 83.3-96.8 % and 70.9-96.6 % at 6 months, respectively. Complications were uncommon. FUS appears to be an effective and safe treatment modality for cervical HPV and SIL.