炎症
发病机制
糖尿病
2型糖尿病
氧化应激
线粒体
疾病
促炎细胞因子
生物信息学
机制(生物学)
医学
生物
2型糖尿病
免疫学
内分泌学
内科学
细胞生物学
哲学
认识论
作者
Yan Wang,Jingwu Wang,Siyu Tao,Zhengting Liang,Ruizhi Xie,Nannan Liu,Ruiguang Deng,Yuelin Zhang,Dayong Deng,Guiyan Jiang
摘要
Abstract The pathogenesis of diabetes is accompanied by increased levels of inflammatory factors, also known as “metabolic inflammation”, which runs through the whole process of the occurrence and development of the disease. Mitochondria, as the key site of glucose and lipid metabolism, is often accompanied by mitochondrial function damage in type 2 diabetes mellitus (T2DM). Damaged mitochondria release pro‐inflammatory factors through damage‐related molecular patterns that activate inflammation pathways and reactions to oxidative stress, further aggravate metabolic disorders, and form a vicious circle. Currently, the pathogenesis of diabetes is still unclear, and clinical treatment focuses primarily on symptomatic intervention of the internal environment of disorders of glucose and lipid metabolism with limited clinical efficacy. The proinflammatory effect of mitochondrial damage‐associated molecular pattern (mtDAMP) in T2DM provides a new research direction for exploring the pathogenesis and intervention targets of T2DM. Therefore, this review covers the most recent findings on the molecular mechanism and related signalling cascades of inflammation caused by mtDAMP in T2DM and discusses its pathogenic role of it in the pathological process of T2DM to search potential intervention targets.
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