Advances of SERS applications in clinic samples analysis

Various diseases have seriously threatened the health of Chinese residents. Sensitive and accurate analysis of disease markers is very important for early diagnosis, treatment, and prognosis evaluation of diseases. Therefore, it is of great clinical significance to explore a sensitive, accurate, rapid, and noninvasive detection technology. Surface-enhanced Raman spectroscopy (SERS) uses light to interact with gold, silver, and other nanostructured materials to generate a strong surface plasmon resonance effect, which can significantly enhance the Raman signal of molecules adsorped on the nanostructured surface, and obtain rich fingerprints of the sample itself or Raman probe molecules with super sensitivity. This technology has the advantages of noninvasiveness, high sensitivity, good selectivity, fast analysis speed, low water interference, and other unique advantages, so it has a good application prospect in life science, clinical testing, and other aspects, and has become a kind of biological detection technology with great potential. This paper mainly reviewed the research progress of SERS technology in the analysis of serum, urine, saliva, and tissue disease markers in recent years analyzed the problems and challenges to be solved by this technology in biological detection and prospected its future development prospects.