创伤性脑损伤
神经炎症
脑震荡
医学
背景(考古学)
炎症
生物信息学
重症监护医学
毒物控制
伤害预防
内科学
精神科
急诊医学
生物
古生物学
作者
Ioannis Mavroudis,Alin Ciobîcă,Alina-Costina Luca,Vasile Burlui,Laura Romila,Alin Constantin Iordache
出处
期刊:Biomedicines
[MDPI AG]
日期:2024-01-26
卷期号:12 (2): 293-293
标识
DOI:10.3390/biomedicines12020293
摘要
Mild traumatic brain injury (mTBI) accounts for most TBI cases, the leading cause of morbidity and mortality worldwide. Despite its high incidence, mTBI pathophysiology remains largely unknown. Recent studies have shown that the inflammatory response is activated early after mTBI and can persist for several weeks or months. However, limited evidence on the utility of inflammatory biomarkers as predictors of clinical outcomes in mTBI has been previously provided. Thus, this systematic review and meta-analysis aims to provide an overview of the current knowledge on the role of inflammation in the pathogenesis of mTBI and the potential of some inflammatory biomolecules as biomarkers of mTBI. In this regard, eight studies comprising 1184 individuals were selected. Thus, it was shown that the increase in IL-6, TNF-α, and IL-1β plasma levels could be implicated in the development of early post-concussion symptoms. On the other hand, the persistence of the increased plasmatic concentrations of IL-10 and IL-8 for as long as six months following the brain injury event could suggest chronic inflammation leading to neuroinflammation and late or persistent symptoms. In this context, our findings showed that inflammatory biomarkers could be relevant in diagnosing or predicting recovery or long-term outcomes of mTBI.
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