A case of recurrent acute pancreatitis due to paliperidone palmitate long-acting injectables (LAI)

Drug-induced pancreatitis is an uncommon but not usually life-threatening adverse reaction to various medications, including several antipsychotics. We are reporting here on the first such case due to a long-acting antipsychotic, paliperidone palmitate, in a patient with schizophrenia that had been stabilised using this medication for more than a year. A subsequent re-challenge led to a second episode of acute pancreatitis, making the aetiological correlation with paliperidone palmitate more definite. Both episodes were resolved with conservative treatment.