C-2 Fluorinated Castanospermines as Potent and Specific α-Glucosidase Inhibitors: Synthesis and Structure-Activity Relationship Study

C-2 Fluorinated castanospermines have been synthesized from a well-protected aldehyde precursor and compared as glycosidase inhibitors with castanospermine, 1-epi-castanospermine and C-1 fluorinated castanospermines. Whereas C-1 fluorinated castanospermines lose nearly all...