Cardiometabolic multimorbidity, social activity, and joint trajectories of physical disability, depressive symptom, and cognitive function in mid-to-late life: a multicohort study

CMM was associated with worse levels, faster progression, and concurrent deterioration in physical disability, depressive symptom, and cognitive function, with the poorest trajectories among those who were socially inactive. This underscores the importance of implementing prevention strategies that integrate physical, psychological, cognitive, and social activities.