An endoplasmic reticulum stress-responsive nanocomposite hydrogel for diabetic wound healing through a fibroblast-immune cell dual regulation hub

cells. This GPHCFD nanocomposite hydrogel integrates ERS-responsive nanoparticle release, fibroblast gene editing, and immune reprogramming, offering a new therapeutic modality for diabetic wounds incorporating tissue regeneration-immune homeostasis synergistic regulation.