神经发生
嗅球
室下区
神经干细胞
侧脑室
神经科学
前脑
生物
利基
干细胞
解剖
细胞生物学
中枢神经系统
生态学
作者
Joanne C. Conover,Krysti L. Todd
标识
DOI:10.1016/j.exger.2016.11.007
摘要
In the anterior forebrain, along the lateral wall of the lateral ventricles, a neurogenic stem cell niche is found in a region referred to as the ventricular-subventricular zone (V-SVZ). In rodents, robust V-SVZ neurogenesis provides new neurons to the olfactory bulb throughout adulthood; however, with increasing age stem cell numbers are reduced and neurogenic capacity is significantly diminished, but new olfactory bulb neurons continue to be produced even in old age. Humans, in contrast, show little to no new neurogenesis after two years of age and whether V-SVZ neural stem cells persist in the adult human brain remains unclear. Here, we review functional and organizational differences in the V-SVZ stem cell niche of mice and humans, and examine how aging affects the V-SVZ niche and its associated functions.
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