Effect of panax notoginseng saponins on hERG potassium channel

Objective:To investigate the effect of panax notoginseng saponins(PNS) on hERG(human ether-a-go-go related gene) potassium channel currents.Methods: Using whole-cell voltage-clamp recording techniques,we observed the effect of various concentrations of PNS on hERG potassium channel in HEK293 cells permanently transfected with this channel.Results: PNS at 100 and 300 μg·mL-1 increased hERG currents in a time-dependent manner in the hERG-transfected cells.Conclusion: PNS can increase hERG potassium currents,which may be associated with the hERG deactivation state.