Metarhizium anisopliae,an important entomopathogenic fungus,plays an important role in pest bio-control.The pesticide developed from entomopathogenic fungi has advantages of lasting action time,non-environmental contamination and safety to non-target organism and disadvantages of lasting lethal time,inefficient and instability control effect,which hinders its widespread application seriously.The paper expounds recognition and conglutination of Metarhizium anisopliae to hosts,appressorium formation of Metarhizium anisopliae during its invasion hosts,its penetration mechanism of Metarhizium anisopliae to host body wall and adaptation mechanism of Metarhizium anisopliae after accessing host hemolymph at molecular level.