Receiver operating characteristic curve applied in screening for transfusion-transmitted virus

Objective To promote ROC curve and to evaluate the decided thresholds and diagnostic performance in TTVs screening in blood station. Methods Enzyme-linked immunosorbent assay was used to detect antibody for hepatitis C virus( anti-HCV) in 56 human plasma( positive 34,negative 22). The cutoff value and accuracy between two diagnostic tests via the ROC curve were determined. Results The best cut point of manufacturer A was 2. 459,with values of sensitivity and specificity 0. 73 and 0. 97,respectively. The area under ROC curve was 0. 9082,which suggested a higher level of diagnostic performance. The test accuracy of manufacturer B was superior to A. Conclusion An optimal statistical index of sensitivity,specificity and Youden value could be calculated by ROC curve. ROC curve leads to more objective results and can evaluate the accuracy and compare between two diagnostic tests in a more reliable way than other indices.