Studies on the preparation of collagen burn pellicle of compound sulfadiazine silver and factors influencing the drug release

Objective: To prepare the collagen burn pellicle of compound sulfadiazine sliver and to investigate the influencing factors of drug release. Methods:The collagen burn pellicle of compound sulfadiazine sliver was prepared by initator method,the release percent was determined by paddle method. Results:A milky white, translucent, smooth and elastic membrane was prepared. The maximal release percent of the collagen burn pellicle of compound sulfadiazine silver was achieved under the conditions of 0.3 mL cross linking agent, 3 hours of cross linking time at 37 ℃ and 3 hours at constant temperature. Conclusion:The collagen burn pellicle of compound sulfadiazine sliver can be easily prepared by initator method.This method is accurate,rapid and simple for the quality control of the collagen burn pellicle of compound sulfadiazine silver.