英夫利昔单抗
医学
炎症性肠病
诺卡菌病
克罗恩病
疾病
并发症
机会性感染
内科学
重症监护医学
诺卡氏菌感染
肿瘤坏死因子α
阿达木单抗
外科
诺卡迪亚
免疫学
病毒性疾病
人类免疫缺陷病毒(HIV)
细菌
生物
遗传学
作者
Rishi Verma,Ritu Walia,Stephen B. Sondike,Raheel Khan
出处
期刊:PubMed
日期:2015-06-09
卷期号:111 (3): 36-9
被引量:4
摘要
Nocardiosis is a serious complication of tumor necrosis factor (TNF) alpha blockers. With the increasing use of biologics for inflammatory bowel disease, it is to be anticipated that opportunistic infections such as nocardia will be more frequently encountered in children. We present the case of a 16 year old male with Crohn's disease who developed pulmonary nocardiosis during the course of his treatment with infliximab. This case illustrates the diagnostic and therapeutic challenges faced in patients with inflammatory bowel disease infected with opportunistic organisms. Pediatric health care providers need to be aware so that early diagnosis and treatment can be provided thereby preventing disseminated disease and having favorable outcomes. Although TNF blocker therapy must be discontinued in the presence of such infections, biologic therapy may be reintroduced after successful treatment with trimethoprim-sulfamethoxazole to control underlying symptoms of inflammatory bowel disease.
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