Study on Effects of Apple Polyphenols on Lead Discharging in Mice

The purpose of this paper was to evaluate the lead discharging effects of apple polyphenol (AP) on male Kunming mice given lead. Lead acetate was administered by intraperitoneal injection for 10 days. Administration of AP to mice by gastric incubation was performed for 15 days from the end of lead exposure up to the end of the experiment. Then, the mice were sacrificed for comparison of lead distribution. Concentrations of lead in the specimens were determinated by graphite furnace atomic absorption spectrophotometry. It was observed that the blood lead, the liver lead and the femur level significantly decreased, but urinates lead elimination significantly increased. The results illustrated that AP could discharge lead .