Oxaliplatin plus fluoriouracil and folinic acid combination chemotherapy in the treatment of colorectal carcinoma

Objectives To evaluate the efficacy and toxicity of home made oxaliplatin plus fluoriouracil, and folinic acid combination therapy in the treatment of colorectal carcinoma.Methods twenty-six cases received oxaliplatin 130mg/m 2,d1;folinic acid 200mg/m 2,d 1-d 5 and fluoriouracil 300mg/m 2,d 1-d 5.The regiment was repeated every 21 days.Results There were Dukes' A 1 case, Dukes'B 7 cases, and Dukes'C+D 18 cases; the overall response rate was 61.5%. The advanced' response rate was 44.4%. The major toxic reactions were nausea, vomiting and peripheral neurotioxixity.Conclusions Oxaliplatin plus fluoriouracil and folinic acid combination therapy is positively effective and cheap in colorectal carcinoma. The toxicity is mild to moderate and reversible.