糖尿病前期
医学
内科学
内分泌学
腹内脂肪
脂肪组织
代谢综合征
甘油三酯
腹部肥胖
肥胖
糖尿病
人口
队列
胰岛素抵抗
胆固醇
2型糖尿病
内脏脂肪
环境卫生
作者
Lei Tang,Fang Zhang,Nanwei Tong
摘要
Summary Objective Abdominal visceral ( VAT ) and subcutaneous ( SAT ) adipose tissues contribute to obesity, but may have different cardiometabolic risk profiles. We examined and compared the associations of abdominal VAT and SAT with metabolic risk factors in a large cohort of Chinese adults. Methods This study was based on cross‐sectional analysis of data from 1449 adults aged 40–65 years. VAT and SAT were assessed at L4–L5 level by magnetic resonance imaging. The associations of VAT and SAT with blood pressure, glucose and lipid were examined by linear regression stratified by sex and glucose tolerance status (normal glucose tolerance and prediabetes). Logistic regression was used to analyse the association of VAT and SAT with risk of hypertension, prediabetes and dyslipidaemia. Results VAT was more strongly associated with metabolic risk factors. Higher VAT was associated with higher blood pressure (β men = 3·99, P = 0·0002; β women = 6·46, P = 0·0002), higher triglyceride (β men = 0·45, P < 0·0001; β women = 0·6, P < 0·0001), higher total cholesterol (β men = 0·15, P = 0·02; β women = 0·37, P = 0·0002) and higher 2‐h glucose levels (β men = 0·68, P = 0·003; β women = 0·94, P < 0·0001). The association remained significant after subjects were stratified by glucose tolerance status. However, SAT was not associated with any additional risk factors. VAT was associated with increased risk of hypertension ( OR = 1·97, P < 0·0001), prediabetes ( OR = 1·53, P = 0·0007) and dyslipidaemia ( OR = 2·40, P < 0·0001). These associations were not observed for SAT . Conclusions VAT was more strongly associated with cardiometabolic risk factors than SAT in a large cohort of Chinese adults. Higher VAT was associated with increased risk of hypertension, dyslipidaemia and prediabetes.
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