生物膜
生物发生
淀粉样蛋白(真菌学)
细胞外基质
细胞生物学
生物
细胞粘附
微生物学
化学
细菌
细胞
生物化学
遗传学
基因
植物
作者
Michelle M. Barnhart,Matthew R. Chapman
出处
期刊:Annual Review of Microbiology
[Annual Reviews]
日期:2006-10-01
卷期号:60 (1): 131-147
被引量:1007
标识
DOI:10.1146/annurev.micro.60.080805.142106
摘要
Curli are the major proteinaceous component of a complex extracellular matrix produced by many Enterobacteriaceae. Curli were first discovered in the late 1980s on Escherichia coli strains that caused bovine mastitis, and have since been implicated in many physiological and pathogenic processes of E. coli and Salmonella spp. Curli fibers are involved in adhesion to surfaces, cell aggregation, and biofilm formation. Curli also mediate host cell adhesion and invasion, and they are potent inducers of the host inflammatory response. The structure and biogenesis of curli are unique among bacterial fibers that have been described to date. Structurally and biochemically, curli belong to a growing class of fibers known as amyloids. Amyloid fiber formation is responsible for several human diseases including Alzheimer's, Huntington's, and prion diseases, although the process of in vivo amyloid formation is not well understood. Curli provide a unique system to study macromolecular assembly in bacteria and in vivo amyloid fiber formation. Here, we review curli biogenesis, regulation, role in biofilm formation, and role in pathogenesis.
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