Patient-specific modelling of cardiovascular dysfunction: Identifying models of pulmonary embolism in pigs

Introduction In an intensive care unit (ICU), cardiac assessment typically relies on a minimal set of measurements such as cardiac output (CO), arterial pressure, and electrocardiogram (ECG). However, significant patient variability that is very difficult to manage. Previous studies [1] have shown the potential for using lumped parameter models of the cardiovascular system (CVS) in a clinical environment. This paper extends the methods to allow robust patient specific modelling with a reduced data set that does not need the previously required ventricle volumes. The approach is validated on a porcine model of Pulmonary Embolism.