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Anti-inflammatory secondary metabolites from Scrophularia kotschyana

芹菜素 木犀草素 化学 传统医学 乙酸乙酯 消炎药 二氯甲烷 丁醇 乙醇 色谱法 药理学 溶剂 类黄酮 生物化学 生物 医学 抗氧化剂
作者
Gülin Renda,Mine Kadıoğlu,Merve Kılıç,Büşra Korkmaz,Hasan Kırmızıbekmez
出处
期刊:Human & Experimental Toxicology [SAGE Publishing]
卷期号:40 (12_suppl): S676-S683 被引量:2
标识
DOI:10.1177/09603271211058889
摘要

The species belonging to Scrophularia genus grow mainly in Irano-Turanian and Mediterranean regions and have been used as folk remedy for inflammatory-related diseases since ancient times. The present study was aimed to evaluate the anti-inflammatory activity of the extracts of Scrophularia kotschyana as well as the isolated compounds. The aerial parts and the roots of the plant were separately extracted with methanol. Anti-inflammatory activities of both extracts were evaluated with formalin test in mice. As the methanolic extract of the aerial parts significantly (p < .05) inhibited inflammation, it was then submitted to successive solvent extractions with n-hexane, dichloromethane, ethyl acetate and n-butanol to yield subextracts. Anti-inflammatory activities of the subextracts were evaluated within the same test system. Among the subextracts tested, the n-butanol subextract produced a significant (p < .05) anti-inflammatory activity at all doses (5, 10, and 30 mg/kg, ip.). Sequential chromatographic separation of the n-butanol subextract yielded 8-O-acetyl-4'-O-(E)-p-coumaroylharpagide, 8-O-acetyl-4'-O-(Z)-p-coumaroylharpagide, β-sitosterol 3-O-β-glucopyranoside, apigenin 7-O-β-glucopyranoside, apigenin 7-O-rutinoside, luteolin 7-O-β-glucopyranoside and luteolin 7-O-rutinoside. The anti-inflammatory activities of the isolates were evaluated at 5 mg/kg dose. Luteolin 7-O-β-glucopyranoside and apigenin 7-O-rutinoside caused a significant (p < .05) inhibition of oedema formation.
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