化学
催化作用
区域选择性
烷基化
筑地反应
镍
药物化学
组合化学
炔丙基
作者
Zhao-Zhao Zhou,Xian-Rong Song,Sha Du,Ke-Jian Xia,Wan-Fa Tian,Qiang Xiao,Yong-Min Liang
摘要
Herein, a highly regioselective alkylation of propargylic carbonates for trisubstituted allenes with alkyl 1,4-dihydropyridine derivatives (1,4-DHPs) is developed via a photoredox/nickel dual-catalyzed process, which represents the first direct approach to access alkylated allene products without alkyl organometallic reagents. This method features a broad substrate scope and mild conditions. A hypothetical mechanism with an alkyl radical and an allenyl Ni(III) species is proposed. Benzylation products were also obtained to be the complement building blocks for the potential synthesis of pharmaceuticals.
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