溶瘤病毒
癌症治疗
病毒
生物
癌症研究
肿瘤细胞
癌细胞
癌症
溶癌病毒
癌症治疗
病毒学
计算生物学
遗传学
作者
Yang Gao,Yan Wu,Hui Tian,Xiaoyan Wang,Jun Xu,Xu Qi,Yue Feng,Haifeng Shi
标识
DOI:10.1007/s10529-021-03173-3
摘要
Oncolytic therapy is a treatment method used to directly combat tumor cells by modifying the genes of naturally occurring low pathogenic viruses to form "rhizobia" virus. By taking the advantage of abnormal signal pathways in cancer cells, it selectively replicates in tumor cells leading to tumor cell lysis and death. At present, clinical studies widely employ biomolecular technology to transform oncolytic viruses to exert stronger oncolytic effects and reduce their adverse reactions. This review summarizes the current progresses and the molecular mechanism of oncolytic viruses towards tumor treatment and management.
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