Protective effects of quercetin against sepsis-induced oxidative damage on rat kidneys

Aim: Sepsis is a clinical pathology, characterized by a severe and exaggerated inflammatory response.One of the most frequently damaged organs in sepsis is the kidney.Quercetin has anti-inflammatory, anti-proliferative, and antioxidant effects.In this study, it was aimed to examine the protective effects of quercetin on the kidneys.Material and Methods: In the scope of this study, 31 rats were planned to be used in the experiments.The groups and number of animals were as follows: Group 1: 1.5 ml saline, Group 2: 1.5 ml olive oil, Group 3: intestinal ligation and puncture procedure was used to create experimental sepsis method.Group 4: 20 mg/kg quercetin was administrated by gavage.Group 5: quercetin was administered in intragastrically at doses of 20 mg/kg.In biochemical analyzes of kidney tissue samples, BUN, creatinine, MDA and GSH values were checked.Cell damage, inflammation and fibrosis were evaluated histopathologically.Results: As a result of this study, tissue GSH levels were significantly different between groups 3 and 4 (p= 0.001).In terms of BUN value, it was found to be significantly higher in group 3 (p= 0.002).In tissue histology, glomerulitis (p= 0.001), tubular cell necrosis (p= 0.001) and mesenchymal matrix increase (p= 0.001) were different between groups 3 and 4. Finally, no fibrosis was observed in any group (p> 0.05).Discussion: Quercetin has protective effects on kidney tissue against organ damage caused by sepsis.