子宫内膜异位症
医学
雌激素
内科学
内分泌学
激素
促性腺激素释放激素激动剂
兴奋剂
促性腺激素释放激素
受体
促黄体激素
标识
DOI:10.1016/0002-9378(92)91706-g
摘要
In women with recurrent pelvic pain caused by endometriosis, hormonal therapy with agonadotropin-releasing hormone agonist is an effective alternative to surgical therapy. The basis for medical treatment of endometriosis is that endometriosis lesions are dependent on estradiol for continued growth. Further, end organ tissue varies in its sensitivity to estradiol. This forms the basis of the estrogen threshold hypothesis, that is, that a concentration of estradiol that will partially prevent bone loss may not stimulate endometrial growth. Thus there is a hierarchy of organ response to estradiol such that calcium metabolism is most sensitive followed by gonadotropin secretion, vaginal epithelial growth, lipid metabolism, and liver protein production. Similarly, breast cancer is most sensitive and endometriosis is least sensitive to estrogen. These differences may allow the design of regimens with a gonadotropin-releasing hormone agonist that maintain a therapeutic response and ameliorate potential adverse effects.
科研通智能强力驱动
Strongly Powered by AbleSci AI