PI3K/AKT/mTOR通路
mTORC1型
RPTOR公司
雷帕霉素的作用靶点
P70-S6激酶1
mTORC2型
细胞生长
细胞生物学
生物
雷氏菌
激酶
蛋白激酶B
核糖体s6激酶
核糖体蛋白s6
信号转导
生物化学
作者
Marie Cargnello,Joseph Tcherkezian,Philippe P. Roux
出处
期刊:Mutagenesis
[Oxford University Press]
日期:2015-02-13
卷期号:30 (2): 169-176
被引量:160
标识
DOI:10.1093/mutage/geu045
摘要
The mechanistic/mammalian target of rapamycin (mTOR) is a conserved protein kinase that controls several anabolic processes required for cell growth and proliferation. As such, mTOR has been implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes and neurodegeneration. As part of the mTOR complex 1 (mTORC1), mTOR regulates cell growth by promoting the biosynthesis of proteins, lipids and nucleic acids. Several mTORC1 substrates have been shown to regulate protein synthesis, including the eukaryotic initiation factor 4E (eIF4E)-binding proteins (4E-BPs) and the ribosomal S6 kinases (S6Ks) 1 and 2. In this work, we focus on the signalling pathways that lie both upstream and downstream of mTORC1, as well as their relevance to human pathologies. We further discuss pharmacological approaches that target mTOR and their applications for the treatment of cancer.
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