环丙沙星
脆弱类杆菌
菌群(微生物学)
粪便
微生物学
抗生素
沙门氏菌
殖民地化
人口
生物
殖民抵抗
细菌
拟杆菌
肠杆菌科
医学
大肠杆菌
生物化学
遗传学
环境卫生
基因
作者
Agnès Perrin-Guyomard,J Poul,Denis E. Corpet,Pascal Sandérs,A. Fernández,Mary J. Bartholomew
标识
DOI:10.1016/j.yrtph.2005.03.001
摘要
A study was conducted to evaluate the effects of therapeutic and residual doses of ciprofloxacin on the human intestinal flora implanted into germ-free mice. Ciprofloxacin was administered daily via drinking water at concentrations to provide doses of 0, 0.125, 1.25, and 12.5mg/kg b.w. Changes in the intestinal flora composition, alteration in bacterial enzyme activities, fecal short chain fatty acid concentration and bacterial cellular fatty acid profiles, overgrowth of resistant bacteria, and disruption of the colonization barrier were the endpoints evaluated in the feces of human-flora-associated (HFA) mice. Ciprofloxacin at all tested doses decreased significantly the aerobic populations and particularly the population of Enterobacteriaceae. Selection of resistant Bacteroides fragilis group was noticed in HFA mice receiving 12.5mg/kg b.w. In mice challenged with a Salmonella strain, exogenous Salmonella persisted in the feces of all treated mice indicating that the flora responsible for the colonization barrier effect was disturbed by the antibiotic treatment. None of the studied metabolic parameters of the flora were affected by ciprofloxacin at any dose level. Under the experimental conditions of the study, the no-observed-effect level of ciprofloxacin was found to be less than 0.125 mg/kg b.w.
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