医学
德诺苏马布
骨重建
骨组织形态计量学
骨病
骨痛
骨架(计算机编程)
疾病
肾功能
外科
骨质疏松症
内科学
泌尿科
小梁骨
解剖
作者
Peter Schwarz,Anne Qvist Rasmussen,Torben Kvist,Ulrik B. Andersen,Niklas Rye Jørgensen
出处
期刊:Bone
[Elsevier]
日期:2012-05-01
卷期号:50 (5): 1023-1025
被引量:50
标识
DOI:10.1016/j.bone.2012.01.020
摘要
Bone affection in Paget's disease is characterized by increased bone turnover localised at one or more sites of the skeleton. Bisphosphonates are the drugs of choice when treating the increased bone turnover in Paget's disease. However, in cases of decreased kidney function only less effective treatments that are available as bisphosphonates are contraindicated in these patients. We present a case of a male patient aged 86 years with GFR of 11 mL/min and Paget's disease successfully treated by Denosumab. The bone turnover and pain decreased upon treatment.
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