血运重建
新生血管
血管内皮生长因子
牙髓(牙)
牙科
医学
微血管
血管生成
臼齿
再植
体内
血管内皮生长因子受体
外科
内科学
生物
心肌梗塞
生物技术
作者
Eoin M. Mullane,Zhihong Dong,Christine M. Sedgley,Jan C.‐C. Hu,Tatiana M. Botero,G. Holland,Jacques E. Nör
标识
DOI:10.1177/154405910808701204
摘要
The long-term outcome of replanted avulsed permanent teeth is frequently compromised by lack of revascularization, resulting in pulp necrosis. The purpose of this study was to evaluate the effects of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF-2) on the revascularization of severed human dental pulps. Tooth slices were prepared from non-carious human molars and treated with 0–50 ng/mL rhVEGF 165 or rhFGF-2 for 7 days in vitro. Both angiogenic factors enhanced pulp microvessel density compared with untreated controls (p < 0.05). Tooth slices were also treated with 0 or 50 ng/mL rhVEGF 165 for one hour prior to implantation into the subcutaneous space of immunodeficient mice. Treatment with rhVEGF 165 increased pulp microvessel density in vivo (p < 0.05). These results demonstrate that rhVEGF 165 enhanced neovascularization of severed human dental pulps and suggest that topical application of an angiogenic factor prior to replantation might be beneficial for the treatment of avulsed teeth.
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