E2F型
秀丽隐杆线虫
生物
转录因子
黑腹果蝇
视网膜母细胞瘤
保守序列
遗传学
细胞生物学
模式生物
抑制器
细胞周期蛋白
视网膜母细胞瘤蛋白
细胞周期
计算生物学
基因
肽序列
作者
Sander van den Heuvel,Nicholas J. Dyson
摘要
Proteins that are related to the retinoblastoma tumour suppressor pRB and the E2F transcription factor are conserved in many species of plants and animals. The mammalian orthologues of pRB and E2F are best known for their roles in cell proliferation, but it has become clear that they affect many biological processes. Here we describe the functions of pRB-related proteins and E2F proteins that have emerged from genetic and biochemical experiments in Caenorhabditis elegans and Drosophila melanogaster. The similarities that have been observed between worms, flies and mammals provide insight into the core activities of pRB and E2F proteins and show how a common regulatory module can control various biological functions in different organisms.
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