Pharmacokinetic Behavior and Appraisal of Intravenous Busulfan Dosing in Infants and Older Children

A population PK model accounting for the highest Bu CL in the youngest patients was validated on training and evaluation data sets. The BW-based dosing strategy recommended in Europe proved to be consistent on a large paediatric cohort representative of the population heterogeneity observed in hematopoietic stem-cell transplantation.