尖孢镰刀菌
烟曲霉
乙酰胺
化学
白色念珠菌
微生物学
立体化学
酰胺
镰刀菌
生物
生物化学
有机化学
植物
作者
Ronglu Yu,Mingzhu Li,Yi Wang,Bai X,Jianwei Chen,Xing‐Nuo Li,Hong Wang,Huawei Zhang
出处
期刊:Records of Natural Products
[ACG Publications]
日期:2020-11-28
卷期号:15 (2): 130-135
被引量:8
标识
DOI:10.25135/rnp.199.20.07.1728
摘要
Chemical investigation of a co-culture of two endophytic fungi Aspergillus fumigatus D and Fusarium oxysporum R1 from two traditional medicinal plants, Edgeworthia chrysantha Lindl. and Rumex madaio Makino, led to isolation of a new amide 1 and six known compounds, including neovasinin (2), neovasifuranone B (3), N-(2-phenylethyl)acetamide (4), α-linolenic acid (5), α-elaeostearic acid (6), palmitoleic acid (7). On the basis of extensive spectroscopic analysis including 1D and 2D NMR, HR-ESI-MS and optical rotation measurement as well as comparison of literature data, chemical structure of 1 was unambiguous elucidated as (S, E)-methyl-2-(2,4-dimethylhex-2-enamido)acetate. Bioassay results indicated that none of these compounds exhibited strong inhibitory effect on three human pathogens Escherichia coli, Staphyloccocus aureus and Candida albicans with MIC values of ≥25 μM.
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