慢性淋巴细胞白血病
ROR1型
癌症研究
滤泡性淋巴瘤
血小板源性生长因子受体
套细胞淋巴瘤
淋巴瘤
白血病
医学
内科学
受体
生长因子
作者
Amir Hossein Daneshmanesh,Anna Porwit,Mohammad Hojjat‐Farsangi,Mahmood Jeddi-Tehrani,Katja Pokrovskaja Tamm,Dan Grandér,Sören Lehmann,Stefan Norin,Fazel Shokri,Hodjattallah Rabbani,Håkan Mellstedt,Anders Österborg
标识
DOI:10.3109/10428194.2012.731599
摘要
The receptor tyrosine kinase ROR1 has been shown to be overexpressed in chronic lymphocytic leukemia (CLL). The aim of this study was to further characterize the expression of ROR1 and the other member of the ROR family, ROR2, in other lymphoid and myeloid malignancies. Normal white blood cells and reactive lymph nodes were negative for ROR1 and ROR2. A significantly high and uniform surface expression of ROR1 was found in CLL/hairy cell leukemia (HCL) compared to mantle cell lymphoma (MCL), marginal zone lymphoma (MZL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), myelomas, acute lymphoblastic leukemia (ALL) and myeloid leukemias (p = 0.02 to < 0.001). The lowest proportion of ROR1+ cells was seen in FL, whereas CLL, HCL and CML had significantly higher numbers of ROR1+ cells. Longitudinal follow-up of individual patients with CLL revealed that ROR1+ cells remained stable over time in non-progressive patients, but increased when the disease progressed (p < 0.05). Thus, a variable staining pattern of ROR1 ranging from very high (CLL, HCL) and high (CML) to intermediate (myeloma and DLBCL) or low (FL) was noted. ROR2 was not detected in hematological malignancies.
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