亲环素A
医学
内科学
内膜中层厚度
生物标志物
冲程(发动机)
心脏病学
亲环素
狭窄
颈动脉
生物
生物化学
机械工程
基因
工程类
分子生物学
作者
Chen‐Shu Chang,Shih‐Li Su,Chen‐Ling Kuo,Ching‐Shan Huang,Wan-Min Tseng,Song‐Shei Lin,Chin‐San Liu
出处
期刊:Current Neurovascular Research
[Bentham Science]
日期:2018-07-30
卷期号:15 (2): 111-119
被引量:11
标识
DOI:10.2174/1567202615666180516120959
摘要
Background: Cyclophilin A plays a pathogenic role in the development and progression of atherosclerosis, which can be assessed by measuring carotid intima-media thickness. The primary aim of this study was to examine the interaction between plasma Cyclophilin A level and carotid intima-media thickness in patients with acute ischemic stroke. Method: Plasma concentration of Cyclophilin A was measured on admission in 66 consecutive patients who had been hospitalized for acute cerebral stroke and in 52 case-control subjects without a history of acute stroke. Subjects in both groups also underwent ultrasound B-mode imaging to measure the mean and maximum intima-media thickness of the carotid artery. Inflammatory biomarkers including high-sensitivity C-reactive protein and fibrinogen were also assessed. Results: We found that the plasma concentration of Cyclophilin A was significantly higher in patients with acute ischemic stroke (p = 0.042). Increased Cyclophilin A was also correlated with carotid intima-media thickness in the patient group (p < 0.001). Among the risk factors for cerebral stroke examined in this study, only hypertension was significantly associated with plasma Cyclophilin A level. Conclusion: Increased plasma Cyclophilin A levels might be involved in the pathophysiology of acute ischemic stroke and Cyclophilin A might serve as a biomarker in risk assessment of acute stroke patients. Keywords: Cyclophilin A, ischemic stroke, inflammation, atherosclerosis, reactive oxygen species, carotid intima-media thickness.
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