生物
E2F型
转录因子
细胞命运测定
基因表达调控
视网膜母细胞瘤蛋白
细胞生物学
细胞周期
遗传学
转录调控
机制(生物学)
基因
视网膜母细胞瘤
抄写(语言学)
计算生物学
认识论
哲学
语言学
作者
Arthur P. Young,Rakesh Nagarajan,Gregory D. Longmore
出处
期刊:Oncogene
[Springer Nature]
日期:2003-10-16
卷期号:22 (46): 7209-7217
被引量:89
标识
DOI:10.1038/sj.onc.1206804
摘要
The E2F family of transcription factors are critical regulators of the cell cycle and have also been implicated in apoptosis, development, DNA damage checkpoints, and differentiation. Retinoblastoma (Rb) proteins interact with E2F to regulate transcription, and several mechanisms have been proposed for Rb-E2F transcriptional regulation. We designed microarray-based experiments to characterize the relative contributions of each mechanism, and unexpectedly, we found that distinct functional gene groups show preference for one mechanism over the others. We propose that such a distribution may provide signaling specificity to enable regulatory proteins to turn on or off entire pathways that determine cell fate.
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