清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

An immunoinformatics-based designed multi-epitope candidate vaccine (mpme-VAC/STV-1) against Mycoplasma pneumoniae

表位 免疫原性 反向疫苗学 生物 病毒学 肺炎支原体 抗原 佐剂 微生物学 免疫学 医学 肺炎 内科学
作者
Thaís Cristina Vilela Rodrigues,Arun Kumar Jaiswal,Marcela Rezende Lemes,Marcos Vinícius da Silva,Helioswilton Sales‐Campos,Luiz Carlos Júnior Alcântara,Sthephane Fraga de Oliveira Tosta,Rodrigo Bentes Kato,Khalid J. Alzahrani,Debmalya Barh,Vasco Azevedo,Sandeep Tiwari,Siomar de Castro Soares
出处
期刊:Computers in Biology and Medicine [Elsevier]
卷期号:142: 105194-105194 被引量:5
标识
DOI:10.1016/j.compbiomed.2021.105194
摘要

Pneumonia is a serious global health problem that accounts for over one million deaths annually. Among the main microorganisms causing pneumonia, Mycoplasma pneumoniae is one of the most common ones for which a vaccine is immediately required. In this context, a multi-epitope vaccine against this pathogen could be the best option that can induce effective immune response avoiding any serious adverse reactions. In this study, using an immunoinformatics approach we have designed a multi-epitope vaccine (mpme-VAC/STV-1) against M. pneumoniae. Our designed mpme-VAC/STV-1 is constructed using CTL (cytotoxic T lymphocyte), HTL (Helper T lymphocyte), and B-cell epitopes. These epitopes are selected from the core proteins of 88 M. pneumoniae genomes that were previously identified through reverse vaccinology approaches. The epitopes were filtered according to their immunogenicity, population coverage, and several other criteria. Sixteen CTL/B- and thirteen HTL/B- epitopes that belong to 5 core proteins were combined together through peptide linkers to develop the mpme-VAC/STV-1. The heat-labile enterotoxin from E. coli was used as an adjuvant. The designed mpme-VAC/STV-1 is predicted to be stable, non-toxic, non-allergenic, non-host homologous, and with required antigenic and immunogenic properties. Docking and molecular dynamic simulation of mpme-VAC/STV-1 shows that it can stimulate TLR2 pathway mediated immunogenic reactions. In silico cloning of mpme-VAC/STV-1 in an expression vector also shows positive results. Finally, the mpme-VAC/STV-1 also shows promising efficacy in immune simulation tests. Therefore, our constructed mpme-VAC/STV-1 could be a safe and effective multi-epitope vaccine for immunization against pneumonia. However, it requires further experimental and clinical validations.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
7秒前
Amosummer发布了新的文献求助10
13秒前
合适依秋完成签到 ,获得积分10
38秒前
blueberry完成签到 ,获得积分10
43秒前
天地一沙鸥完成签到,获得积分10
53秒前
zhangxr完成签到 ,获得积分10
59秒前
机智的小羊尾完成签到 ,获得积分10
1分钟前
喵喵完成签到 ,获得积分10
1分钟前
完美世界应助科研通管家采纳,获得10
1分钟前
lanxinge完成签到 ,获得积分10
1分钟前
阜睿完成签到 ,获得积分10
2分钟前
tongluobing完成签到,获得积分10
2分钟前
skkstar完成签到 ,获得积分0
2分钟前
桂花完成签到 ,获得积分10
2分钟前
小鱼女侠完成签到 ,获得积分10
2分钟前
chcmy完成签到 ,获得积分10
2分钟前
2分钟前
xczhu完成签到,获得积分10
3分钟前
mgqqlwq发布了新的文献求助10
3分钟前
hello完成签到,获得积分10
3分钟前
3分钟前
筱泉发布了新的文献求助10
3分钟前
隐形曼青应助筱泉采纳,获得10
3分钟前
蓝色白羊完成签到 ,获得积分10
3分钟前
林玉完成签到 ,获得积分10
3分钟前
jlwang发布了新的文献求助10
3分钟前
Eric完成签到 ,获得积分10
4分钟前
伶俐海安完成签到 ,获得积分10
4分钟前
宇文非笑完成签到 ,获得积分10
4分钟前
科研佟完成签到 ,获得积分10
4分钟前
zhang完成签到 ,获得积分10
4分钟前
yi完成签到,获得积分10
4分钟前
mgqqlwq完成签到,获得积分10
5分钟前
April完成签到 ,获得积分10
5分钟前
MMY完成签到,获得积分10
5分钟前
5分钟前
5分钟前
童童应助科研通管家采纳,获得10
5分钟前
啦啦啦完成签到 ,获得积分10
5分钟前
长卿123发布了新的文献求助10
5分钟前
高分求助中
Un calendrier babylonien des travaux, des signes et des mois: Séries iqqur îpuš 1036
Sustainable Land Management: Strategies to Cope with the Marginalisation of Agriculture 1000
Corrosion and Oxygen Control 600
Python Programming for Linguistics and Digital Humanities: Applications for Text-Focused Fields 500
Heterocyclic Stilbene and Bibenzyl Derivatives in Liverworts: Distribution, Structures, Total Synthesis and Biological Activity 500
重庆市新能源汽车产业大数据招商指南(两链两图两池两库两平台两清单两报告) 400
Division and square root. Digit-recurrence algorithms and implementations 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2546000
求助须知:如何正确求助?哪些是违规求助? 2175672
关于积分的说明 5600229
捐赠科研通 1896383
什么是DOI,文献DOI怎么找? 946268
版权声明 565379
科研通“疑难数据库(出版商)”最低求助积分说明 503557