甲基丙烯酰胺
明胶
PLGA公司
脚手架
乙醇酸
材料科学
极限抗拉强度
静电纺丝
化学工程
组织工程
复合材料
乳酸
生物医学工程
化学
共聚物
纳米技术
聚合物
有机化学
工程类
遗传学
细菌
生物
丙烯酰胺
医学
纳米颗粒
作者
Zhi Hong Xie,Wei‐Chang Li,Xiaomin Sun,Zhanyi Lin,Ren Li
出处
期刊:ACS applied polymer materials
[American Chemical Society]
日期:2022-01-10
卷期号:4 (2): 987-998
被引量:4
标识
DOI:10.1021/acsapm.1c01442
摘要
Although electrospun vascular scaffolds are becoming a center of artificial blood vessel scaffold research because of their ability to promote organizational reconstruction, the mechanical and biological properties of initial electrospun scaffolds are relatively insufficient. The poor mechanical properties of electrospun scaffolds are mostly attributed to their high porosity and weak bonding at fiber junctions. To further improve these properties, they were post-treated by heat treatment, crosslinking, and solvent-vapor welding. In this study, coaxial electrospun poly (lactic-co-glycolic acid) (PLGA)/gelatin methacrylamide (GelMA) composite scaffolds were developed with PLGA and heparin as the core component and GelMA as the shell component. Then, the PLGA/GelMA (P/G) scaffolds were post-treated by four methods, which were crosslinked in deionized water (P/G-CDI), crosslinked in GelMA solution (P/G-CG), heating annealing (P/G-HA), and solvent-vapor annealing (P/G-SA). Compared to the P/G scaffold, the fibers of the electrospun scaffolds after post-treatment were bonded, and the porosity and degradation rate were reduced. The P/G-CG scaffold exhibited optimized mechanical properties and bioactivities. After immersing the P/G scaffold in GelMA solution and UV crosslinking, the tensile strength of the P/G-CG scaffold was greatly improved by 2.5 times compared to that of the P/G scaffold. Moreover, the P/G-CG scaffold supported the adhesion and proliferation of human umbilical vein endothelial cells (HUVECs) better than the P/G, P/G-CDI, and P/G-HA scaffolds. Overall, the results suggest that the modified P/G-CG scaffold possesses better performance in vascular application.
科研通智能强力驱动
Strongly Powered by AbleSci AI